Generating human oligodendrocyte precursor cells from adult human dermal fibroblasts for the treatment of spinal cord injury.
|Host institution||The University of Auckland|
|Post‐Doctoral Research Fellow||Dr Amy McCaughey‐Chapman|
|Funding term||24 months|
Oligodendrocytes are cells in the central nervous system that produce a protective, insulating layer called myelin which allows electrical impulses to propagate quickly and efficiently between neurons. This study will investigate whether human oligodendrocyte precursor cells generated from human skin cells can be used for cell transplantation to promote remyelination following spinal cord injury.
Remyelination is the natural repair mechanism of demyelination, it is proposed that remyelination protects against progressive axonal injury and consequently also diminishes long-term disability. Endogenous remyelination takes place following spinal cord injury, but this is not sufficient for repair and hence transplantation of exogenous oligodendrocyte precursor cells to promote and enhance remyelination is an exciting prospect.